Midleton CBS was founded by the Congregation of Christian Brothers in 1867.

[1] The Christian Brothers arrived in Midleton in 1867 at the request of the parish priest who recognized the need of a dedicated school to educate the town's Roman Catholic male youth, at a time when the Church of Ireland's Midleton College was fast expanding.

The local community provided donations for the cost of the construction, and the school opened on 3 April 1867, with over 300 pupils joining in its first week.

[3] The school buildings were massively extended in the 2010s, in a project which cost €12.6 million.

The curriculum teaches first years: Religion; Irish as L2; English as L1; Mathematics; French as L2; German as L2; Science; Business Studies; History; Geography; CSPE; SPHE; Woodwork; Technical Graphics; Art; Music; Technology and Physical Education.