The school is known locally as "The Brothers, Omagh CBS" or "Scoil Ghramadaí na mBráithre Críostaí, An Omaigh", which is its native name in Irish.

"The Brothers" in Omagh were given the responsibility of ensuring that "Education be gratuitous and the admission free."

[5][verification needed] On its first day of activity one hundred and twenty boys, all aged between five and fifteen, showed up.

the Strule Shared Education Campus is the largest ever school-building project in Northern Ireland hye.

[6] On 18 July 2024, the Northern Ireland Executive gave the project the go ahead, with the Department of Education minister Paul Givan saying the project is "a new and pioneering approach which will inform the future development of education in Northern Ireland over the coming decades".

These values focus on teaching and lifelong learning, caring for one another, the development of the Catholic faith, transformational leadership and a genuine sense of community and partnership.

Additionally, the school places an expectation that boys' shirts should always be buttoned at the neck and cuffs, and ties should be properly worn.

[3] Boys are only permitted to wear formal style black leather shoes or boots.

[3] In 2018, 94.2% of its entrants achieved five or more GCSEs at grades A* to C, including the core subjects English and Maths.

[10] The school had an overall attendance rate of 89.6% (2021–22), and in 2023, had 950 boys enrolled (exclusive of statemented students) and 135 admissions.

The School also focuses on the teachings of the Catholic faith, making Religious Studies compulsory at GCSE, and A-Level.

The Christian Brothers' Grammar School, Omagh offers a full school curriculum, including;[3] As well as meeting the Northern Ireland statutory entitlement for curriculum provision, the Christian Brothers' Grammar School aims to ensure its curriculum provision to allow every pupil to fulfil his academic potential, meet the individual learning needs of every pupil by ensuring the curriculum is diverse, stimulating and tailored to the employment needs of our local and global economy.