Born in Mthatha, Eastern Cape, South Africa,[1] she gained public recognition for her feature on DJ Zinhle's song, "My Name Is", after being discovered by Kalawa Jazmee's CEO Oskido.

[5] When she was young, her family relocated to Durban due to work by her parents[5] At the age of 15, Gqulu grew passion for writing poems.

She also hosted her monthly poetry events which are called "1st Word Sessions" at the Bat Centre in Durban.

[8] Gqulu and Sir Bubzin were later signed to Kalawa Record by the CEO, Oskido, after he heard the song.

[20] Later that year, Gqulu was called by Oskido to record "My Name Is Busiswa" which was produced by DJ Zintle.

[9] The song was a hit and It received extensive airplays in South African radio stations since its release.

[25] In November 2013, Gqulu released a single, "Lahla"[26] featuring Dj Bucks and Uhuru.

[28][29] In September 2016, Gqulu joined the fourth season of Clash of the Choirs, as a Choirmaster with Kelly Khumalo,[30] Anele Mdoda,[31] JR, Bucie,[32] Sifiso Ncwane and IFANI.

Throughout the remainder of 2017, Gqulu was featured on several singles including Tipcee "Isichathulo" and Dj Maphorisa "Vuvushka" and "Midnight Starring".

[42] In 2020, she collaborated with South African Amapiano musician, Gaba Cannal on the single Umhlaba Wonke.

[46] Gqulu spent her early years under the care and guidance of her late mother and grandmother who were a great influence in shaping her strong personality.

[49][50] In March 2021, her own-created documentary-reality show title "Her Majesty: Busiswa" premiered on BET Africa.

[52] Gqulu also works with the Umlazi District Department of Education's Youth Development Office, tutoring learners on public speaking, debating and performance poetry.