Considered the largest used academic bookstore between Chicago and New York, it contains thousands of used books, scholarly and otherwise from a wide range of fields.

In 2007, Harrisburg Area Community College opened its new Midtown campus at the corner of 3rd and Reilly streets in the renovated Evangelical Press Building.

From 2019 to 2022, HACC began to leave its Midtown 2 building by the end of its lease, opting to relocate the programming to its main Wildwood campus to save money.

The Harrisburg Midtown Arts Center (H•MAC) occupies the formerly abandoned Police Athletic League building on Third Street, which operates two performance venues with a bar and restaurant.

This is primarily due to a strong housing stock for renovation and proximity to the Central Business District, which has been experiencing growth itself.