In January 1959, the university added a graduate school which received full approval from the State Board of Education in August of that year.

[7] From its beginnings as a municipal junior college housed in a high school building, Midwestern has become a state university whose campus of 255 acres and 70 buildings offers a wide variety of academic programs in liberal and fine arts, mathematics, sciences, business, and applied sciences.

[7] On March 9, 2015, the university announced that Suzanne Shipley was selected to become its next president, following Jesse Rogers' retirement after 48 years of service to the school.

[9] The Robert and Carol Gunn College of Health Sciences and Human Services officially opened up their new building, Centennial Hall, on September 6, 2019.

The Dalquest Desert Research Station[15] is located on 3,000 acres of West Texas soil north of the Big Bend Ranch State Park.

The land was a gift from Walter W. Dalquest, a professor at MSU, and his wife, Rose, on the condition that it be used for scientific research by biologists and geologists.

The university's campus covers 255 acres (1.0 km2) with over 50 buildings uniformly built of red brick with tiled roofs and arched facades.

The campus newspaper and production studio are housed in the Mass Communication wing of the Fain Fine Arts Center.