The district boundaries coincide with the boundaries of Mifflin County, minus the southwestern municipalities of Kistler and Newton Hamilton boroughs and Wayne Township, which are part of the Mount Union Area School District.

Mifflin County School District encompasses approximately 362.3 square miles.

Based on 2020 federal census data, the district's resident population shrank to 43,285.

[1] According to the Pennsylvania Budget and Policy Center, 48.9% of the District's pupils lived at 185% or below the Federal Poverty level as shown by their eligibility for the federal free or reduced price school meal programs in 2012.

[7] According to District officials, in the 2013-2014 school year, Mifflin County School District provided basic educational services to 5,436 pupils through the employment of 400 administrators and teachers and 214 full-time and part-time non-instructional staff.

It reported employing: 384 teachers, 229 full-time and part-time support personnel, and increasing to 30 administrators.

[8] In 2008, the District employed: 460 teachers, 402 full-time and part-time support personnel, and 27 administrators.

The Tuscarora Intermediate Unit 11 provides the district with a wide variety of services like specialized education for disabled students and hearing, speech and visual disability services and professional development for staff and faculty.

The following are the current members of the Mifflin County School District Board of Directors.

Brown Elementary School - Mascot: Bear 96 Kish Rd., Reedsville, Pennsylvania 17084.

Closed in June 2005 (Merged with Seventh Ward and Buchanan to form Lewistown Elementary School).

Strodes Mills Middle School - Mascot: Panther 205 Chestnut Ridge Road, McVeytown, PA 17051.