(In the newer edition, the last chapter Migraine Aura and Hallucinatory Constants was written in collaboration with Ralph M.

[2]) As with Sacks's other writings, Migraine is a comprehensive review of the subject aimed at the lay population and uses numerous case histories.

[3] Sacks describes the nature of and treatments for migraine in general and several various subtypes, particularly examining the visual aura feature that is common to many sufferers, along with the pre-migraine signs & symptoms.

[3] The book is divided into five sections:[3] In an interview with Neil deGrasse Tyson about the possible merits of altered states of consciousness by means of psychoactive substance, Sacks revealed that in 1967 he had a revelation when he was under the influence of an undisclosed psychoactive substance while reading a book written in the 19th century about headaches and migraines.

This book was written by Edward Liveing, an early and important contributor in theories of migraine pathogenesis.