[1] The bout was at Madison Square Garden, in New York City, United States under the promotion of Top Rank at a catchweight of 153 pounds.

After uniting with famed trainer, Emmanuel Steward, Cotto became Light Middleweight champion when he defeated Yuri Foreman, in a very bizarre way,[6] at the Yankee Stadium[7] on June 5, 2010.

With his corner growing even more concerned as time passed and the punishment on their fighter mounted, they threw in the towel stopping the fight in round 8.

He made one defense of his world title on March 12, 2011, against Ricardo Mayorga, with a technical knockout in the 12th round, at the MGM Grand Arena in Las Vegas.

[11] He fought Manny Pacquiao for a vacant Light Middleweight title suffering a one-sided decision loss before a delighted crowd of 41,734 at Cowboys Stadium in Arlington, Texas.

He had his orbital bone broken and also developed a large cataract in the right eye as a result of Pacquiao's repeated blows.

Margarito was originally told he could continue to box only as long as he didn't have cataract surgery, but that the blurry vision in his right eye would not improve.

[15] New York State Athletic Commission (NYSAC) initially denied Margarito a boxing license on October 31, 2011.

An appeal was filed and a hearing took place to where several leading eye doctors testified that Margarito should be allowed to fight.

[19] HBO aired a brief interview, confrontational-styled show entitled, "Face Off" with Max Kellerman hosting and leading the conversation.

Cotto controlled the fight from the outset, landing at a high connect percentage and parrying and dodging the majority of Margarito's shots.

Doctors finally stopped the fight before the 10th round because of the worsening condition of Margarito's eye, awarding Cotto a 9th-round TKO victory.