Reale graduated from the Law Faculty of the University of São Paulo (1934), where he was professor (1941) and rector (1949-1950, 1969-1973).

In 1969 he was appointed by President Arthur da Costa e Silva for "High Level Commission" set up to review the 1967 Constitution.

In 2002 Reale, Ada Pellegrini Grinover, Maria Helena Diniz and Gofredo da Silva Teles Júnior actively participated in the important drafting of the Brazilian Civil Code.

Special Rapporteur on the XII, XIII and XIV World Congress of Philosophy (Venice, 1958, and Mexico City, 1963, and Vienna, 1968).

Lecturer specially invited by the International Federation of Philosophical Societies for the XVI and XVIII World Congress (Düsseldorf, Germany, 1978, and Brighton, UK, 1988).