Apart from her group's activities, Mijoo has starred in various Korean variety shows such as, Hit The Stage (2016), Dunia: Into a New World (2018), Sixth Sense (2020–2022), Hangout with Yoo (2021) and season 2 of Learn Way (2021–2022).

[6] The group's debut studio album Girls' Invasion was officially released on November 17, along with its lead single titled "Candy Jelly Love".

[citation needed] In 2020, Mijoo starred in the first season of tvN's Sixth Sense alongside Yoo Jae-seok, Jeon So-min, Oh Na-ra, and Jessi.

In Episode 124 which aired in July 2022, it was confirmed that Mijoo alongside Haha, Shin Bong-sun, and Jeong Jun-ha would be officially become the fixed cast members of Hangout With Yoo.

[22] In April 2022, Mijoo was announced as one of the cast members of JTBC's new music variety show New Festa along with You Hee-yeol, Yoon Jong-shin, Lee Sang Soon, Gummy, and Kyu-hyun.

[23] In July 2022, Mijoo teamed up with Boom once again to be the MC of JTBC's short-form video challenge program, I Want to Be A Celebrity, along with cast members Shortbox, Aiki, Winner's Lee Seung-hoon, Kim Gye-ran, Pony, and Shin Ji-yeon.

[24] Mijoo joined wavve dating program Some-ping as an MC along with Jo Se-ho, Uhm Ji-yoon, and Winner's Kang Seung-yoon and Kim Jin-woo which premiered in August 2022.

[32] On August 12, 2022, Mijoo donated ₩30 million to help those affected by the 2022 South Korean floods through the Hope Bridge Korea Disaster Relief Association.

[42] On May 30, 2022, Lotte Confectionery announced the selection of Lee Mijoo as the face of a new advertising campaign for their ice cream product Seolleim due to her "bright and cheerful image" and her "great influence on Generation Z customers".

[43] In May 2022, Lee Mijoo was chosen as one of eight models for travel brand goodchoice's summer campaign along with Yoon Jong-shin, Chang Kiha, Noh Hong-chul, Jang Yoon-ju, Meenoi, Anupam Tripathi, and Pani Bottle.

[36] On April 18, 2024, Mijoo's agency, Antenna Entertainment, confirmed the reports that were circulating that she is in a romantic relationship with professional football goalkeeper Song Bum-keun.