In 2013, she started a charity Lady Garden Foundation, which aims to raise awareness of gynaecological cancers and fund research into treatments.

[14] Aged six, her family moved to Somerset where she attended Wellsway Comprehensive school and joined Bristol Youth Theatre.

[17][18] In 2002, she appeared in Channel 4's TV movie, Falling Apart, a period drama, about domestic violence in a middle-class relationship in Britain.

[30] In 2023, Simmons played Jill in Disruption at Off West End Park Theatre alongside Nathaniel Curtis.

[45][46] Simmons is one of the six women who in 2013 co-founded the Lady Garden Foundation, a charity which raises awareness and funding for gynaecological health.

[52] It has raised over £1,000,000 since 2014 to assist research at the Royal Marsden Hospital into treatments including the use of Olaparib, led by Susana Banerjee who inspired Simmons to start the foundation.