Mikalojus Radvila or Mikołaj I[2] nicknamed the Old (Lithuanian: Mikalojus Radvilaitis, Mikalojus II Radvila Senasis, Polish: Mikołaj Radziwiłłowicz Stary, Latin: Nicolaus II Radziwil Priscus) (c. 1450 – 16 July 1509) was a Lithuanian noble.

He was the Voivod of Vilnius since 1492 and the first Grand Chancellor of Lithuania from 1504 until his death in 1509.

His sons Jerzy, Mikołaj, and Jan were the progenitors of the three Radziwiłł family lines.

His daughter Anna was the great-grandmother of Elizabeth Báthory.

This biographical article about a member of the Lithuanian nobility is a stub.