He left Maipú for Buenos Aires in search of fame in 1992, and initially struggled in a variety of menial jobs, living hand-to-mouth in a tenement for a number of years.

He was eventually discovered by a modeling agency and in 1992, was given a small role in leading local comic Guillermo Francella's sitcom, La familia Benvenuto.

He later appeared in the popular teen drama, Montaña rusa ("Rollercoaster"), and in the mid-1990s, enrolled in a theatre school, mentored first by Santiago Doria, and later, Alfredo Zemma, of the Argentine Actors' Association.

[3] He was given his first film role by directors Florencia Di Baja and Germán Drexler, as the leading man in their comedy, Tus ojos brillaban (Bright Eyes), in 2004, and was reunited with Francella in 2005 in his top-rated sitcom, Casados con hijos ("Married with Children").

Amigorena was among the Argentine actors asked to appear in Francis Ford Coppola's production set in Buenos Aires, Tetro (2009).