Mike De Palmer (October 17, 1961 – August 7, 2021) was a professional tennis player from the United States.

During his career, he won six tour doubles titles and finished runner-up an additional six times.

DePalmer had a career high singles ranking of 35, with wins over Jimmy Connors, Vitas Gerulaitis, Mel Purcell, Peter Fleming, Peter Lundgren, Paul McNamee, Jakob Hlasek, and Tim Gullikson.

He reached the singles final in Ancona, Italy, in 1982, losing to Anders Järryd 6-3, 6-2.

De Palmer died in Knoxville, Tennessee, on August 7, 2021, at the age of 59 because of complications from pancreatic cancer.