[9][10][11] Hughes made headlines with his game-sealing 95-yard kickoff return in the November 24, 2017, War on I–4 game against the South Florida Bulls,[12][13][14][15] with Orlando Sentinel writer Shannon Green remarking that the play saved the undefeated season for the Knights.

[25] On October 14, 2018, in a Week 6 game against the Arizona Cardinals, Hughes suffered a torn ACL, prematurely ending his rookie season.

In Week 9 against the Kansas City Chiefs, Hughes forced a fumble on rookie wide receiver Mecole Hardman on a kickoff return and the ball was recovered by teammate Holton Hill in the 26–23 loss.

[30] The Vikings declined to exercise the fifth year option on Hughes' contract on May 3, 2021, making him an unrestricted free agent following the 2021 season.

[32] In Week 1 against the Cleveland Browns, Hughes intercepted a pass from Baker Mayfield late in the 4th quarter sealing a Chiefs 33–29 victory.

[37] Hughes was named a starting cornerback for Atlanta entering the 2024 season, beating out Clark Phillips III for the role.