In Game 7 of the 2014 World Series, with the Royals down by one run with two outs in the bottom of the ninth against San Francisco Giants ace pitcher Madison Bumgarner, Alex Gordon hit a single to left field; Giants left fielder Gregor Blanco misplayed the ball, and Gordon advanced to third base where Jirschele stopped him.

The next batter was catcher Salvador Pérez, who popped out to third baseman Pablo Sandoval in foul territory to end the game and the series in favor of the Giants.

When Blue Jays right fielder José Bautista threw to second base, Jirschele sent Cain home to score the run that would send the Royals back to the World Series, where they defeated the New York Mets in five games to win the team's second championship.

Following the 2021 season, Jirschele, along with 2021 River Bandits manager Chris Widger were transferred to the Royals’ Double-A affiliate, the Northwest Arkansas Naturals.

On April 8, he recorded his 1,000th win as manager of Omaha’s Triple-A team, as the Storm Chasers defeated the Toledo Mud Hens, 13-8.

His son Justin played minor league baseball for four seasons in the Chicago White Sox organization before retiring in 2015.