He has worked alongside artists such as the Weeknd, Daft Punk, Kanye West, A$AP Rocky, Electric Youth, Haim, Miss Kittin, The Hacker, Jean-Michel Jarre, Lil Nas X, Charli XCX, and Pharrell Williams.

Gesaffelstein is a portmanteau of Gesamtkunstwerk ("total artwork" in German, also the title of an album by the American electro group Dopplereffekt) and Albert Einstein.

[9] His remix of "Shockwave" by The Hacker is featured in the 2013 video game Grand Theft Auto V, on the Soulwax FM radio station.

In 2015, Gesaffelstein released the single "Conquistador" in collaboration with Jean-Michel Jarre, which is present on the album Electronica 1: The Time Machine.

[11] Gesaffelstein signed to Columbia Records in November 2018, with whom he released the lead single "Reset" from his second studio album Hyperion in the same month.

[4] Megan Buerger from the Washington Post describes his style as a mixture of dark and underground music, and notes that a specialty of the artist is his use of silences to create a "tension" before a "raucous explosion of bass and percussion".