He has also created other supernatural and paranormal themed titles for Dark Horse including Baltimore, Joe Golem, and The Amazing Screw-On Head.

[6] In 1983 he worked as an inker at Marvel Comics on Daredevil and Power Man and Iron Fist and later became the penciler on titles such as The Incredible Hulk, Alpha Flight, and the Rocket Raccoon limited series.

His visual depiction of the Joker anticipated prospective advertisements for his work in Gotham by Gaslight, yet the cover text still adhered to the "Death in the Family" storyline.

Mignola included a black-and-white police sketch in Gotham by Gaslight that did not replicate his Batman #429 cover art, choosing instead to root that Elseworlds incarnation of the Joker in Conrad Veidt's 1928 portrayal of Gwynplaine for The Man Who Laughs.

A scene from Tim Burton's Batman, released in June 1989 (United States), additionally featured Jack Nicholson's Joker in a top hat, but without a monocle.

In 1990–1991, they produced the Fafhrd and the Gray Mouser limited series for Epic Comics, with inker Al Williamson.

That year, Dark Horse Comics released Hellboy: Seed of Destruction, Mignola's creator-owned project.

Since then all Hellboy stories have been written solely by Mignola with the exception of They That Go Down to the Sea in Ships, which was co-written by Joshua Dysart.

Other artists have also had a hand in drawing flashback stories including Jason Shawn Alexander, Kevin Nowlan and Scott Hampton.

In 2007, following after 2005's The Island, British artist Duncan Fegredo took over art duties on the ongoing story arc of Hellboy from Darkness Calls onwards.

Since then it has had several short stories and beginning in 2013 it became an ongoing series with Scott Allie as the lead writer with Mignola.

: Hell on Earth is the main series continuing after the catastrophic events at the conclusion of the Plague of Frogs cycle.

Continuing where Hell on Earth left off, The Devil You Know is written by Mike Mignola and Scott Allie with Laurence Campbell serving as the regular artist.

Numerous spinoffs have been published that are set in the Hellboy universe: Baltimore began with a 2007 illustrated novel, and continued as a comic book series.

It was created by Mike Mignola and Christopher Golden and exists in a shared universe with Baltimore called "The Outerverse".

[22] Mignola worked as an illustrator for Francis Ford Coppola's 1992 movie Bram Stoker's Dracula.

He was also the production designer for the Disney feature film Atlantis: The Lost Empire in 2001 and a concept artist for 2002's Blade II and Pixar's Brave.

[citation needed] Mignola was hired by Bruce Timm to provide character designs for Batman: The Animated Series in 1991.

Mignola's The Amazing Screw-On Head debuted in 2006 on the Sci-Fi Channel, starring the voices of Paul Giamatti and David Hyde Pierce.

[24] Mignola also co-wrote the screenplay for a 2024 reboot film titled Hellboy: The Crooked Man alongside Chris Golden.

Directed by Kevin Konrad Hanna and Jim Demonakos, this film explores Mignola's journey in creating the Hellboy series and features interviews with industry figures like Guillermo del Toro and Neil Gaiman.