There were several lineup changes before Muir hired Grant Estes, Louiche Mayorga and Amery Smith on guitar, bass and drums respectively.

In 1983, they released their self-titled album, with success sparked by the anthem song "Institutionalized", which would become one of the first hardcore punk videos to receive substantial airplay on MTV.

Cited as one of the most important crossover thrash groups,[citation needed] Suicidal Tendencies was active until 1995, but reunited a year later.

Los Cycos eventually included: Grant Estes on lead guitar, Gallo went to (rhythm), and original choices Bob Heathcote and Amery Smith were replaced by Louiche Mayorga (bass) and No Mercy's Sal Troy (drums).

[11] Mike Muir's vocals can be heard on the Suicidal Tendencies cut "Look Up...(The Boys are Back)" and the Los Cycos track "It's Not Easy".

[citation needed] Muir has released solo albums under his nickname Cyco Miko and has sung for No Mercy, replacing original singer Kevin Guercio, who sang for the band on the Welcome to Venice compilation.

In 1989, not long after Robert Trujillo joined Suicidal Tendencies, Muir and Trujillo formed Infectious Grooves, a funk metal band that often brought out a goofier type of humor: their albums contain comedy skits by a reptilian lover named Aladdin Sarsippius Sulemenagic Jackson III.

The two worked with each other for the LA Times in the late 1970s before Muir formed Suicidal Tendencies and Paxton started his career in Hollywood.

Following Paxton's death in 2017, Muir expressed in a tribute his condolences to the late actor on Suicidal Tendencies' Facebook page.

He has long been an opponent of the Parents Music Resource Center (PMRC), and has reflected this in interviews and a few songs (namely "You Can't Bring Me Down" and "Lovely").

Muir was involved in a near-violent feud with Megadeth frontman Dave Mustaine during the European Clash of the Titans tour, but the two have since reconciled and are apparently now on friendly terms.

[19][20] Muir later stated that Rage Against the Machine's guitarist, Tom Morello, provoked the feud by attacking Suicidal Tendencies.