It is located on Nellis Air Force Base in Clark County, Nevada and is run by the 99th Medical Group (MDG).

The Air Force provides executive oversight of the facility, staffs all outpatient activities/clinics and inpatient beds for Department of Defense (DoD) beneficiaries.

Fully integrated into the Clark County emergency medical services (EMS) system, Mike O’Callaghan Military Medical Center (MOMMC) is the only hospital and only trauma center in northeast Las Vegas.

It was renamed Mike O'Callaghan Federal Medical Center in January 2012.

It was renamed Mike O'Callaghan Military Medical Center in March 2017.