He played for the Philadelphia Flyers and Toronto Maple Leafs, and was previously the head coach of the Grand Rapids Griffins of the AHL, the Owen Sound Attack of the OHL, the Moose Jaw Warriors of the Western Hockey League, and the Ontario Reign of the American Hockey League.

On June 21, 1988, the Maple Leafs sent Stothers back to the Philadelphia Flyers for Bill Root, however he would spend the last 4 years of his playing career with the Hershey Bears of the AHL.

In 1989–90, Stothers would see his production slip to 7 points (1G-6A) in 56 games as the Bears failed to make the playoffs.

Mike Stothers was an assistant coach with the Hershey Bears, the Philadelphia Flyers AHL affiliate, from 1992 to 1996.

On July 17, 2002, Stothers would leave the Flyers organization to take the head coaching job of the Owen Sound Attack of the OHL.

The Attack would then go on to lost in a hard-fought 7-game series against the Guelph Storm, who went on to win the league championship that season.

[2] In July 2014, Stothers was named the new head coach for the Manchester Monarchs, an affiliate team of the L.A.

Stothers then moved with the franchise to Ontario, California in 2015, and he remained with the team until his contract was not renewed in May 2020.

He joined the Anaheim Ducks as an assistant to head coach Dallas Eakins on June 15, 2021.