Mike Tyson vs. Clifford Etienne, billed as Back to Business, was a professional boxing match contested on February 22, 2003.

In his previous fight on June 8, 2002, Mike Tyson had met WBC and IBF heavyweight champion Lennox Lewis.

Tyson would start the match aggressively by throwing powerful combinations at Etienne, causing Etienne to clinch with Tyson, though the combined momentum of the two fighters caused both men to stumble to the mat and the referee then called a brief timeout to allow the fighters to regroup from the fall.

After the fight was resumed, Tyson continued to throw wild power punches at Etienne, though none connected.

[7] Immediately after his impressive victory over Etienne, Jim Gray conducted an interview with Tyson and asked him if the rematch with Lewis was next.