Mike Tyson vs. Marvis Frazier was a professional boxing match contested on July 26, 1986.

Prior to fighting Frazier, Tyson had fought nine times in 1986 and defeated all but two fighters by knockout, as former championship challenger James Tillis and Mitch Green had taken him to decision victories; he also had initially defeated Jesse Ferguson by disqualification, but the fight result was changed to a knockout.

Holmes, who would later be stripped by the WBC for accepting this fight over a mandatory defense against Greg Page, dominated the younger Frazier and knocked him out in one round.

[3] Following his loss to Holmes, Frazier rebounded to win his next six fights, including unanimous decision victories over Tillis and future world champion James "Bonecrusher" Smith, to get back into contention.

Frazier, however, came into his fight with Tyson as an overwhelming underdog, leading some to criticize his father, manager and trainer Joe for overmatching him.