In Soviet Union, Russia, and outside Shultz is primarily known for his research in the chemical thermodynamics of heterogeneous chemical compounds, electrochemistry of glasses, membrane electrochemistry; for works in the field of ion exchange and phase equilibria of multicomponent compounds, and theory of glass electrode; Shultz also worked on thermal protection system for the Soviet Buran spacecraft and credited with research in optical fibers in 80s.

His works helped to contribute into creation of early pH-meters and ionometry, production organisation, instrumentation and materials commonly used in medicine, chemical and nuclear industry, aviation rocket and space technology, agriculture and many other areas.

[5][6] Mikhail Shultz is the author of fundamental works on physical chemistry, thermodynamics, chemistry and electrochemistry of glass, membrane electrochemistry, the theory of ion-exchange and phase equilibria of multi-component systems, for a total of more than 500 scientific papers, including several monographs, and approximately 20 inventions[9] His name had to do with the beginning of developing pH-metry and ionometry, the creation and organisation of measuring equipment production, widely used in medicine, chemical and nuclear industry, aerospace technology, agriculture and many other fields.

Special mention should be made of the generalisation of the stability conditions for the Gibbs equilibrium to heterogeneous (multicomponent, multiphase) systems (1954).

[8] Data from M. Schulz and staff of his laboratory are exceptional interest for interpretation of Mössbauer's spectra, where the range assessment all of possible states of iron atoms is extremely wide and difficult.

[8] According to the concept of glass developed by M. Shultz, in analogy with pH for aqueous solutions he proposed an innovative idea to establish for glasses and melts—the degree of acidity pO (negative logarithm of the activity of oxygen ions O2−) and standards for methods of measurement: pO is inversely proportional to the degree of basicity and concentration of the oxide.