[2][4] Many of her publications were about the Siouan people, and wrote several important articles on French exploration in the Central and Southern Plains.

[6][9] Wedel served as a field director at an excavation project attributed to the Woodland period near Webster City and the Boone River channel, under the supervision of Charles Reuben Keyes in June and July 1938.

[1][6] At the time of their marriage, her husband was the assistant curator of archaeology at the United States National Museum (now the Smithsonian Institution).

[6] From 1945 after World War II until the 1960s, she helped her husband with the Smithsonian Institution's salvage archaeological projects held primary in the Dakotas; and she took her educational experiences from Sara Jones Tucker and expanded it by focusing on her own ethnohistory research (which is an overlap between anthropology and history).

[6] She did extensive research on French exploration in the Central and Southern Plains, specifically Jean-Baptiste Bénard de la Harpe, Sieur de la Harpe, Pierre-Charles Le Sueur, Claude Charles Du Tisne, and Jean-Baptiste Trutdeau.