He spent the following season with the Single-A Bowling Green Hot Rods, playing in 104 games and batting .264/.346/.348 with 3 home runs, 39 RBI, and 18 stolen bases.

[4] In 2018, Mastrobuoni again played in 104 games, split between the High-A Charlotte Stone Crabs and Double-A Montgomery Biscuits.

[8] Mastrobuoni was assigned to Triple-A Durham to begin the 2022 season, where he spent the majority of the year.

[10] The following day, Mastrobuoni collected his first MLB hit, a single off of Anthony Bass of the Toronto Blue Jays.

[15] On July 21, 2023, Mastrobuoni hit his first career home run against Jack Flaherty of the St. Louis Cardinals.

Mastrobuoni made 50 appearances for Chicago during the 2024 campaign, batting .194/.245/.224 with no home runs, four RBI, and two stolen bases.