Milica Despina (Serbian Cyrillic: Милица Деспина; Romanian: Milița Despina; c. 1485 – 30 January 1554) was the Princess consort of Wallachia by marriage to Neagoe Basarab (r. 1512–1521).

Princess Milica Despina was of Serbian origin, and closely related to noble houses of Branković and Lazarević.

Some scholars think that she was one of the daughters of Serbian despot Jovan Branković who died in 1502.

[1] Others think that she was daughter of Jovan's elder brother, Serbian despot Đorđe Branković who died in 1516.

[2] Milica Despina and Neagoe Basarab had six children: