[4] Mane was born in Paras village of Akola district.
His father was a gateman with the Indian Railways, who was an alcoholic, the family sank in poverty.
Poverty forced Mane as a child and youth to do various types of farm jobs, hawking and menial work, and at one time he was forced to beg for a living for several days.
He studied dentistry for six months, however he shifted to studying medicine on obtaining admission to Indira Gandhi Government Medical college, from where he secured his MBBS degree.
[5] Mane is a vocal supporter of LGBTQ rights in the region.