Enemies such as the Kokuyo Gang, a group of Mafia criminals, and The Varia, an elite team of assassins, prove to be formidable challenges for Tsuna and his comrades.
When some of the characters are later transported into an alternate future, nine years and ten months later, they have to adapt to a world where every Vongola member, as well as their allies, is being hunted down by a powerful rival family, the Millefiore.
[2] The experimentation on him resulted in his ability to gain the attributes of certain animals, like wolves and lions, when he changes to different sets of teeth, increasing his agility, strength, and senses.
She is originally a girl named Nagi who was found by Mukuro when on the verge of death after her attempt to rescue a cat from traffic accident at the cost of her right eye and several of her organs.
Due to the ball's snake-like engravings on the surface, it can track and redirect air currents that create a vortex, sucking in whatever is near, and allowing Lancia to change its rotation in mid-air.
[11][17] In the future, during the attack on the Millefiore, he defeats Sil and Olgelt with his animal box weapon containing a liger that possesses the Sky and Storm Flames.
Xanxus also owns two guns, and can compress his flame into its bullets, utilizing the skill originally developed by Vongola VII to amplify their penetrative and destructive capability.
[citation needed] Superbia Squalo (スペルビ スクアーロ, Superubi Sukuāro) is a gifted swordsman extremely loyal to Xanxus and also Dino's schoolmate from childhood.
He battles and loses to Takeshi Yamamoto during the Vongola Tournament, and though he appears to be eaten by a shark, he had apparently been rescued by Dino in order to get Squalo to reveal information on Xanxus.
In the future, Squalo and Belphegor appears in an encoded video for Tsuna and his family, warning them not to move from their current location and that instructions will be arriving shortly.
After Ryohei destroys the lights and shatters his knee plate, the rest of the Varia assume his loss, and Gola Moska shoots him in the back, making him unable to continue the fight.
In the future, along with retaining his combat abilities, he uses a special box that can unleash a sun-based peacock that can heal wounds while also accelerating a person's hair and nail growth.
Gola Moska (ゴーラ•モスカ, Gōra Mosuka) is a killing machine sold to the Varia on the black market by the Italian government, and is powered by the life of a human.
Introduced during the Varia attack on a Millefiore base in Italy, Fran is Mammon's replacement as the group's illusionist and is thus forced to wear a large frog hat to symbolize this.
Though he possesses the Sky Mare Ring, he has purposefully hidden his true abilities, and maintains a carefree attitude, even during his fight with Mukuro Rokudo, whom he critically injures.
Uni[31][32] (ユニ, Yuni) is a young girl who is the former leader of the Giglio Nero Family as a result of the early death of her mother, Aria, whom she did not know was a Mafia boss.
He is sent to Japan by Byakuran in order to protect Shoichi Irie, so during the Vongola's raid on their base, he defeats Yamamoto and battles adult Hibari until the latter is replaced with their past self.
This leads him to go to great lengths to prove his loyalty to Byakuran, even being consumed by his Hell Ring, which changes him physically and mentally, in order to defeat Tsuna in battle.
Originally thought to have been killed by Bel, Sil reveals himself as the one responsible for the Millefiore defense in Italy, and uses a box weapon containing multiple bats that emit invisible storm flames to assault his enemies in battle.
These members are Shitt P., Adelheid Suzuki, Kaoru Mizuno, Large Ooyama, Kouyou Aoba, Julie Kato, and the tenth Simon boss, Enma Kozato.
Large Ooyama (大山 らうじ, Ōyama Rauji) is the Simon Guardian of the Mountain who gives off the impression of liking kids, not minding Lambo bossing him around all the time.
She has a single patch of hair on her forehead and is always seen wearing two large inflatable rings around herself, prompting Gokudera to label her an "UMA" (Unidentified Mysterious Animal).
When he later learns of Demon Spade's manipulation of the Simon family, he battles against him but is easily outmatched and imprisoned along with Adelheid because he no longer has any capability to fight the Vongola.
Julie Kato (加藤ジュリー, Katō Jurī) is the Simon Guardian of the Desert, who takes a keen interest in Chrome and constantly pushes Enma's to carry out the fight.
After they were defeated by Tsuna and his friends, they agreed to protect the Tri-ni-set for eternity that had been place in jars specifically created by Talbot with Bermuda's Flame of Night as support to prevent another generations of Arcobaleno.
After defeated by Tsuna, he and the Vindice agreed to protect the Tri-ni-set with his flames to take control over it, away from Checker Face, as well as in order to prevent another generation Arcobaleno to be born ever again.
Being the founder of the Flame of Night and formerly the strongest Arcobaleno, Bermuda is a powerful fighter with the ability to short warp an infinite number of times, strong enough to corner Reborn in his adult form.
He, along with Big Pino ambushed Team Verde's decoy puppets and then fought illusions created by Chrome and Flan with Gokudera and Yamamoto mixed among them to buy times until Tsuna, Enma, and Basil arrives.
He, along with Small Gia ambushed Team Verde's decoy puppets and then fought illusions created by Chrome and Flan with Gokudera and Yamamoto mixed among them to buy times until Tsuna, Enma, and Basil arrives.
Sparrow describes the new villains as the "super-powered cadre of bad guys,"[40] with Manga Life's David Rasmussen commenting that Mukuro is an evil being.