Named after doctors Bob and Jim Miller, MHS opened in January 1964.
It is the only secondary institution in the Southern Local School District, which was formed in 1961 with the consolidation of Central School(Hemlock), Corning, Shawnee, Moxahala, and New Straitsville School Districts.
The home of the falcons, Miller High School's official colors are purple and white.
The Falcons belong to the Ohio High School Athletic Association (OHSAA) and were formerly members of the Tri-Valley Conference.
In 2020, Miller joined the Mid-State League's Cardinal Division.