Millers Creek is a census-designated place (CDP) in Wilkes County, North Carolina, United States.

According to the United States Census Bureau, the CDP has a total area of 4.5 square miles (12 km2), all land.

As of the 2020 United States census, there were 1,931 people, 747 households, and 393 families residing in the CDP.

As of the census[3] of 2010, there were 2,112 people, 892 households, and 621 families residing in the CDP.

26.2% of all households were made up of individuals, and 12.0% had someone living alone who was 65 years of age or older.