Mulberry is a census-designated place (CDP) in Wilkes County, North Carolina, United States.

According to the United States Census Bureau, the CDP has a total area of 5.1 square miles (13.2 km2), all land.

Mulberry is located where the foothills of the Blue Ridge Mountains level off to the rolling countryside and small valleys of North Carolina's Piedmont region.

The area is heavily forested, with numerous small cattle and poultry farms, as well as housing developments.

21.4% of all households were made up of individuals, and 7.8% had someone living alone who was 65 years of age or older.