It is centered in the borough of Millville and also serves the townships of Pine, Greenwood, and Madison.

Millville Area School District encompasses approximately 91 square miles (240 km2).

[2] According to the Pennsylvania Budget and Policy Center, 38.8% of the district's pupils lived at 185% or below the Federal Poverty level as shown by their eligibility for the federal free or reduced price school meal programs in 2012.

The Central Susquehanna Intermediate Unit IU16 provides the district with a wide variety of services like specialized education for disabled students and hearing, speech and visual disability services and professional development for staff and faculty.

The Millville Area School District offers a variety of clubs, activities and sports programs.