After architecture and painting studies, he made his comics debut in 1969 drawing for Genius, a fumetti neri series of pocket books from publisher Furio Vanio in the wake of the popularity of Kriminal and Satanik.

[1] In 1970, he illustrated for the magazine Terror, and starting in 1971 drew the erotic series Jolanda de Almaviva written by Francisco Rubino, issued in small format by publisher Erregi.

Manara and Pisú later went on to publish Lo Scimmiotto (The Ape) along the story of the Chinese Monkey King in Alter Linus in 1976, and with Alfredo Castelli, L'Uomo delle Nevi (The Snowman) in 1978.

[2] Manara's reputation for producing comics that revolve around elegant, beautiful women caught up in unlikely and fantastical erotic scenarios became solidified with work such as Il Gioco (1983, also known as Click or Le Déclic), about a device which renders women helplessly aroused; Il Profumo dell'invisibile (1986, Butterscotch), introducing the heroine Miele (Honey) and a sweet-smelling body-paint which makes the wearer invisible; and Candid camera (1988, Hidden Camera), featuring the same protagonist in further explicit adventures.

Rossi declared: "He has drawn some kind of a mythical history of my life, in cartoons, with some of my heroes such as Steve McQueen, Enzo Ferrari, Jim Morrison, and other characters such as my dog Guido, the chicken Osvaldo and a lot of beautiful women!