He is known for his 2006 short story collection Voodoo Heart, and his work for DC Comics, including series such as American Vampire, Detective Comics, a highly acclaimed run on Batman, Swamp Thing, and Justice League as well as the company-wide crossover storylines "Dark Nights: Metal" and "Dark Nights: Death Metal."

He was also influenced by the writing of Denis Johnson, Raymond Carver, Rick Bass, Joy Williams, Elizabeth McKracken, Stephen King, Tobias Wolff, and George Saunders.

[8] Snyder graduated from Brown University in 1998 with a degree in creative writing, and then worked at Walt Disney World for about a year.

[13] Stephen King picked two of the included stories—"Wreck" and "Dumpster Tuesday"—for the 2007 The Best American Short Stories anthology shortlist.

[25] Beginning in September 2011, Snyder became the writer of both Batman[26][27] and a new Swamp Thing ongoing series as part of The New 52, DC Comics' company-wide relaunch of all of its titles.

[28][29][30] Snyder's Batman series reinivisioned the classic character for the New 52's rebooted continuity, garnering acclaim from critics and fans.

[15] The series follows marine biologist Lee Archer, who along with the Department of Homeland Security, discovers a potential threat to humanity that may involve strange, humanoid creatures that inhabit the ocean depths.

[43] In 2016, Snyder and artist John Romita Jr. collaborated on the All-Star Batman series as part of the DC Rebirth relaunch.

[54] In 2020, he and Greg Capullo released the DC Black Label miniseries Batman: Last Knight on Earth, described as "the grand finale" of their New 52 run.

[56] Snyder's Image series Nocterra, drawn by Detective Comics artist Tony S. Daniel, was launched in March 2021[57] following a Kickstarter campaign for the first issue.

[59] In July 2021, Snyder announced an eight-title digital first deal with comiXology Originals, all to be published through his creator-owned imprint Best Jackett Press, with the books set to receive print versions via Dark Horse Comics.

[63] An animated television series adaptation of Wytches was announced by Amazon Prime Video in February 2023,[64] with Snyder serving as co-showrunner.

[67] Snyder was also announced as the co-writer, alongside Joshua Williamson, of DC All In Special #1, an oversized one-shot flipbook with art by Daniel Sampere and Wes Craig that will kick off the initiative.