Milton De Lano (August 11, 1844 – January 2, 1922) was an American businessman and United States representative from New York.

Born in Wampsville, he attended the common schools and settled in Canastota, New York, where he engaged in mercantile pursuits for eight years.

He engaged in banking, the real-estate business, and in the manufacture of window glass.

De Lano was a member of the Canastota Board of Education from 1883 to 1905 and served as president from 1893 to 1905; aided in the organization of the Canastota Northern Railroad Company, and was a delegate to the Republican National Convention in 1884.

He died in Syracuse; interment was in Mount Pleasant Cemetery, Canastota.