Milton Ernest is a village and civil parish in Bedfordshire, England, about 5 miles (8.0 km) north of Bedford itself.

[1] The village is situated on the east bank of the River Great Ouse, and is the site of Milton Ernest Hall, which was used as the United States Eighth Air Force's support command headquarters in the Second World War.

On 15 December 1944, Glenn Miller took off from RAF Twinwood Farm, in neighbouring Clapham, on his last, ill-fated flight, and was last seen in public in the Queen's Head Hotel in Milton Ernest before he disappeared.

A plaque at Milton Ernest Hall honours Major Glenn Miller and members of the United States Eighth Air Force, it reads "In memory of all the personnel who served in World War II at Milton Ernest Hall headquarters USAAF Eight Air Force Service Command Station 608 1943-1946, also Major Glenn Miller & the band of the Allied Expeditionary Force who were stationed here from July to December 1944".

The controversial Yarl's Wood Immigration Removal Centre is located in the parish.