The only Panther to appear in a Major League Baseball game is outfielder Daulton Varsho, who debuted for the Arizona Diamondbacks in 2020.

The Milwaukee men's soccer team has made six NCAA tournaments since 2002, including four straight where they advanced to the second round.

In the 2004 and 2005 tournaments, the Panthers lost to the top team in the country in the second round: 2004 against UC Santa Barbara in double-overtime and 2005 against New Mexico on penalty kicks.

Panthers men's soccer holds the attendance record for Engelmann Stadium, which was set during a match against cross-town rival Marquette on September 3, 2015, with a crowd of 4,030.

Milwaukee's highest end-of-season ranking is 23, which they achieved in 2011 following a Horizon League Championship and a win in the NCAA tournament at home against Illinois State.

The women's volleyball team at Milwaukee has also enjoyed national success in recent years, qualifying for six of the last nine NCAA Tournaments and compiling an all-time record of 867–477–7 through the end of the 2006 season.