Born in Penne, Pescara, Locasciulli is the son of a vet who in his spare time used to perform as a crooner with the stage name Guido Lucas.

[1] Locasciulli made his discographic debut in 1975, and after a couple of commercial disappointments he had his first success in 1982, with the album Intorno a trent'anni, produced by Francesco De Gregori.

[1][2] In 1985 he entered the competition at the Sanremo Music Festival, ranking nineteenth with the song "Buona fortuna".

[1][3] Between 1985 and 1987 he toured with Enrico Ruggeri, then in 1988 Locasciulli started an acclaimed collaboration with the jazz bassist Greg Cohen.

[2] Starting from the 1990s, following the critically acclaimed album Tango dietro l'angolo, he mainly focused on his activity as a producer and on in his day job as a primary care physician.