[1][2][3][4][5] Erythranthe guttata is a model organism for biological studies, and in that context is still referred to as Mimulus guttatus.

[7] For combined research of evolution, genetics, and ecology, particularly plant-insect interactions, the yellow monkeyflower has become a model system.

With the help of physically resistant protections called trichomes, which have been thoroughly examined, the yellow monkeyflower defends itself against herbivores.

The lower lip may have one large to many small red to reddish brown spots (hence the name guttata, which is Latin for 'spotted').

[16][17] Erythranthe nasuta (Mimulus nasutus) evolved from E. guttata in central California between 200,000 and 500,000 years ago and since then has become primarily a self-pollinator.

[20] A herbaceous wildflower, Erythranthe guttata grows along the banks of streams and seeps throughout much of western North America from sea level to 12,000 feet (3,700 m).

[21] It is found in a wide range of habitats including the splash zone of the Pacific Ocean, the chaparral of California, Western U.S. deserts, the geysers of Yellowstone National Park, alpine meadows, serpentine barrens, and even on the toxic tailings of copper mines.