Minadora Orjonikidze (Georgian: მინადორა ორჯონიკიძე; 14 March 1879 — 19 October 1967) was a Georgian politician, active in the Democratic Republic of Georgia and its Constituent Assembly.

Trained as a physician at the University of Geneva, Orjonikidze became familiar with Marxism while there, and married Malakia Toroshelidze, a fellow Georgian Marxist while studying there.

On their return to Georgia Orjonikidze became an active member of the revolutionary movement, though with the 1905 split between Bolsheviks and Mensheviks she follow the majority of Georgians and became a Menshevik.

Arrested again in the 1930s, her husband and two sons were shot while she was exiled to the Kazakh SSR.

[1] Her cousin was Sergo Ordzhonikidze, who would become a prominent Bolshevik and close ally of Joseph Stalin.