Minamiise (南伊勢町, Minamiise-chō) is a town located in Watarai District, Mie Prefecture, Japan.

Minamiise occupies a ria coastal region with numerous deeply indented bays located in the eastern part of the Kii Peninsula in central Mie Prefecture, along the Kumano Sea.

Minamiise has a Humid subtropical climate (Köppen Cfa) characterized by warm summers and cool winters with light to no snowfall.

Minamiise has a mayor-council form of government with a directly elected mayor and a unicameral city council of 14 members.

In terms of national politics, the town is part of Mie 4th district of the lower house of the Diet of Japan.