Mindkiller is a 1982 science fiction novel by American writer Spider Robinson.

The novel, set in the late 1980s (re-edited later to begin in 2006), explores the social implications of technologies to manipulate the brain, beginning with wireheading, the use of electric current to stimulate the pleasure center of the brain in order to achieve a narcotic high.

The novel follows three central characters: Karen Scholz, a young woman who has attempted suicide by permanent wireheading, the constant use of which overrides desires for food and drink; Norman Kent, a college professor, whose life is turned into a quest when his sister is abducted by a powerful authority; and Joe Templeton, a high-tech burglar, who has lost his memory after an accident during wartime.

The novel incorporates as its second chapter a slightly modified version of his short story "God Is an Iron" (first published in the May 1979 issue of Omni), a social commentary on the nature of addiction and addictive personalities built on wireheading.

[1] Dave Langford reviewed Mindkiller for White Dwarf #71, and stated that "One can't help suspecting that this over-intensity is meant to distract you from the dodgy coincidences and out-of character behaviour required to drive the plot.. .