The Venezuelan Ministry of People's Power for Defense (Spanish: Ministerio del Poder Popular para la Defensa) is the federal-level organization responsible for maintaining the Venezuelan armed forces.

As of October 2014, this ministry is headed by General Vladimir Padrino López.

The ministry coordinates numerous counter-narcotics operations (e.g., Operation Sierra through the CUFAN organ), helps perform various civil support and social development programs, and oversees the conventional military capabilities of Venezuela.