The incumbent minister is Sandra Pettovello, who has served since 10 December 2023 in the cabinet of Javier Milei, who created the ministry through a presidential decree.

[1] During the presidential campaign, Javier Milei promised to reduce the number of existing ministries and create new bodies which would bring together several areas in order to cut public expenditure.

[2] On 10 December 2023, on his very first day as President of Argentina, Milei modified the law through a Necessity and Urgency Decree and reduced the previous 19 government ministries to nine.

[3] While planned to be removed and included in this portfolio, the Ministry of Health was ultimately kept by the president and attributed to cardiologist Mario Russo.

[5] A member of the liberal conservative UCEDE party who campaigned for La Libertad Avanza and a former journalist, she was elected National Deputy for Buenos Aires before being appointed minister.