Shortly after the Hellenic Army entered Thessaloniki on 26 October 1912, King Constantine I demanded that he be given control of the newly acquired region of Macedonia,[4] but Prime Minister Eleftherios Venizelos had already decided that the fate of the region would lie with his minister of justice, Konstantinos Raktivan, who arrived in the city on 30 October.

[4] Raktivan was later succeeded by other prominent politicians of Greece, such as Stefanos Dragoumis, Emmanouil Repoulis and Themistoklis Sofoulis.

Despite its limited freedom of action in later years, the Governorate-General of Macedonia managed to produce an astonishing amount of work between its founding in 1912 and the creation of the Ministry of Northern Greece in 1955.

The Governorate-General was also responsible for the complete incorporation of Macedonia into the Greek state despite the difficult circumstances of the interwar period.

[5][7] In particular, the ministry gathers information regarding the communities that fall under its jurisdiction and proceeds to propose and discuss legislation and policies with other government bodies.