The ministry received its last name in 2019 in the cabinet of President Alberto Fernández; its last minister is Daniel Scioli.

It was dissolved in August 2022 as part of a cabinet reorganization process; the Production portfolio currently stands as a secretariat of the Ministry of Economy.

[5] At the time of its dissolution in August 2022, the Ministry of Productive Development counted with a number of centralized and decentralized dependencies.

The centralized dependencies, as in other government ministers, were known as secretariats (secretarías) and undersecretariats (subsecretarías), as well as a number of other centralized agencies:[6][7] Several decentralized agencies also reported to the Ministry of Productive Development, such as the National Institute of Industrial Technology (INTI), the National Institute of Industrial Property (INPI), the Buenos Aires Central Market, and the Banco de Inversión y Comercio Exterior.

[11] The building was built in two stages from 1937 to 1950 and stands on Hipólito Yrigoyen street, across from the emblematic Plaza de Mayo square and the Casa Rosada, seat of the Presidency.