The ministry was dissolved following a presidential decree from President Javier Milei, and turned into a Secretariat.

The first minister responsible was army colonel Juan Francisco Castro, who was in office until 1952.

The centralized dependencies, as in other government ministers, were known as secretariats (secretarías) and undersecretariats (subsecretarías):[8][9] Several decentralized agencies also reported to the Ministry of Transport, such as the National Road Safety Agency (ANSV), the National Transport Regulation Commission (CNRT), the Transport Safety Board, the National Civil Aviation Administration (ANAC), the Civil Aviation Accident Investigation Board, the National Airports System Regulatory Body (ORSNA), the Argentine National Transport Institute, and the General Ports Administration (AGP).

[10][11][12] Several state-owned enterprises were also overseen by the Ministry of Transport, such as Argentina's flag carrier Aerolíneas Argentinas, Operadora Ferroviaria S.E., Ferrocarriles Argentinos, ADIFSE, and Trenes Argentinos Cargas.

[13] The Ministry's headquarters was built in two stages between 1937 and 1950 and is located on Hipólito Yrigoyen street, across from the Casa Rosada and Plaza de Mayo.