The Ministry of the Interior and Public Security (Spanish: Ministerio del Interior y Seguridad Pública) is the cabinet-level office of home affairs in Chile, in charge of "maintaining public order, security and social peace" within the country.

It is also charged with planning, directing, coordinating, executing, controlling, and informing the domestic policies formulated by the President of Chile.

The office officially first came to be on 27 October 1812, when it was one of the two secretariats created by the Constitutional Norms approved on that date.

During this period, its functions normally subsumed the future Ministry of Foreign Affairs, which was separated as an independent government administration in 1871.

This ministry has undergone several reorganizations during its long history, reflected in its different names: The function of chief of government was unofficially assumed by the Minister of the Interior and Public Security (1891–1925).