State Highway 106 serves as a north–south route between Deer Creek and New York Mills in west-central Minnesota.

The route is located in Otter Tail County.

The speed limit from north of Deer Creek to US 10 is 60 mph (95 km/h) and 30 mph (50 km/h) inside the Deer Creek city limits to its southern end at MN 29.

Highway 106 crosses the Leaf River in Deer Creek Township.

[4] The entire route is in Otter Tail County.